Catenin



Catenins (CTN) are proteins which make complexes with cadherin. α-CTN links cadherin (CDH) and α-actinin, it is encoded by 3 genes: α-E-CTN (epithelial), α-T-CTN (membrane bound), and α-N-CTN (neuronal). β-CTN is a subunit of the cadherin complex. It contains armadillo repeats which are a pair of helices forming hairpin structure. γ-CTN (or plakoglobin) is a component of desmosomes and contains armadillo repeats. δ-CTN is expressed in the brain and contains 10 armadillo repeats. p120 CTN is another member of the CTN family. The images at the left and at the right correspond to one representative Catenin, i.e. the crystal structure of full-length zebrafish β-catenin (2z6g).

P120 CTN
3l6x, 3l6y – p120 CTN (mutant) +E-CDH – human

α-CTN
1l7c – mα-CTN C-terminal - mouse

1h6g - hα-CTN M domain

1dov - mα-CTN dimerization domain

1dow - mα-CTN dimerization domain+ mβ-CTN chimera

β-CTN
3diw – mβ-CTN C-terminal+Tax interaction protein 1

2z6g - β-CTN – zebrafish

2z6h - hβ-CTN C-terminal

2gl7 - hβ-CTN (mutant)+TCF-4+B-cell lymphoma protein

2g57 - β-CTN fragment – NMR

3bct, 2bct - mβ-CTN armadillo repeats

1v18 - mβ-CTN armadillo repeats+apc protein

1t08 - hβ-CTN armadillo repeats+apc protein+ hβ-CTN interacting protein

1th1 - hβ-CTN armadillo repeats+apc protein

1qz7 - hβ-CTN armadillo repeats+axis inhibition protein

1g3j - hβ-CTN armadillo repeats+TCF3-CBD

1p22 - hβ-CTN +skp1+trcp1

1luj - hβ-CTN C-terminal+ hβ-CTN interacting protein

1jdh, 1jpw - hβ-CTN C-terminal+HTCF-4

1m1e - mβ-CTN armadillo repeats + mβ-CTN interacting protein

1jpp - mβ-CTN armadillo repeats+apc protein

1i7x, 1i7w - mβ-CTN armadillo repeats+E-CDH

3ouw, 3oux - mβ-CTN+lymphoid enhancer-binding factor 1

γ-CTN
3ifq – hγ-CTN+E-CDH EC1+EC2+EC3